Botulinum toxin injection (Botox) for treatment of chronic migraine, dystonias and post-stroke spasticity

“Best results are expected with skilled procedure, proper muscle selection and appropriate dosage of botulinum toxin (botox)”, says Dr K M Hassan, Recipient of Times Healthcare Achiever’s Award 2018 for Delhi NCR in Legend Category for Neurology

What is botulinum toxin (botox)?

Botulinum toxin (BTX) is a neurotoxic protein produced by bacterium Clostridium botulinum. BTX types A and B are used in neurological practice to treat muscle spasms/stiffness and diseases characterised by overactive muscles. Botox and Dysport are the most commonly available commercial forms, and botox is the most popular formulation in clinical use.

How does botulinum toxin (botox) help?

BTX relieves muscle spasm and stiffness, and also helps reduce pain thereby improving quality of life. Botox therapy is a key component of neurorehabilitation for post-stroke spasticity and cerebral palsy.

What are the neurological conditions in which botulinum toxin (botox) is beneficial?

BTX is used to treat a number of neurological disorders:

  • Post-stroke spasticity, spasticity of multiple sclerosis, post-head injury & post-spinal cord injury
  • Cerebral palsy
  • Chronic migraine
  • Dystonias – blepharospasm (abnormal contraction of eyelids), hemifacial spasm (involuntary contraction of one side of face), cervical dystonia (involuntary contraction of neck muscles causing awkward postures),oromandibular dystonia (forceful contraction of face, jaw, tongue), writer’s cramp (cramps/spasms of muscles of hand and/or forearm during writing),spasmodic dysphonia (strained voice)
  • Chronic muscle pain
  • How does botulinum toxin (botox) work?

    BTX prevents release of neurotransmitter acetylcholine from nerve endings at neuromuscular junction which stops nerves from signalling leading to decreased muscle tone.

    How is botulinum toxin (botox) administered?

    Botox is injected by Neurologists with special interest in management of dystonias and spasticity. BTX is injected at multiple sites into overactive muscles or underneath skin depending on the neurological condition. Results are best in skilled hands with proper muscle selection and appropriate dosage of BTX.

    How long does the effect of botulinum toxin (botox) last?

    Induced weakness of overactive muscles is temporary and repeat injections of BTX are required after 3 to 6 months depending on the clinical condition.

    Is botulinum toxin (botox) safe in clinical practice?

    BTX is generally considered safe in clinical setting. Rarely, BTX can spread to distant areas andreduce tone of unintended muscles.

    Botulinum toxin (botox) therapy at Jaypee Hospital

    The author has vast experience and expertise in botox therapy bringing succour to hapless patients of disabling dystonias, post-stroke spasticity, chronic migraine and cerebral palsy.

    Dr. KM Hassan
    Department of Neurosciences (HOD, Neurology)
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