A 20-day-old baby was referred to our hospital on prostaglandin infusion. He had been diagnosed with a critical aortic stenosis; dysplastic aortic valve and coarctation of the aorta. The baby had been on prostaglandin infusion since birth. Initial evaluation revealed a thickened bicuspid aortic valve with severe LV dysfunction – LVEF 20%. There was a large PDA and the aortic arch appeared to be mildly narrow just opposite to the site of the PDA. The initial haematological evaluations revealed a deranged elevated white cell count and CRP. Keeping in view the critical condition, the patient underwent balloon dilatation of aortic valve under antibiotic cover – Vancomycin and Meropenem. The aortic annulus measured 5.5mm on 2D echocardiography. Balloon dilatation of aortic valve was done using 5mmx2cm Tyshak balloon, keeping annulus to balloon ratio of 0.9. Post balloon dilatation, the pressure gradient across the aortic valve dropped to 30mmHg with mild aortic valve incompetence. Ventricular function normalised after 48 hours. The baby underwent PDA ligation after 3 days as the PDA failed to close after stopping prostaglandin infusion. The initial blood cultures grew candida and gram-negative bacteria. Patient developed features of capillary leak and multi-organ dysfunction despite proper antibiotic coverage. The child had extremely slow recovery and a prolonged ICU stay despite successful cardiac interventions. Child finaly succumbed to ongoing gram negative multiresistant sepsis.